2024

Trofimova, A.; White, B.; Diaz, D. B.; Sirvinskas, M.; Lough, A.; Dudding, T.; Yudin, A. K. A Boron Scan Of Ethyl Acetoacetate Leads To Versatile Building Blocks. Angewandte Chemie 2024, e202319842.

Huh, S.; Batistatou, N.; Wang, J.; Saunders, G. J.; Kritzer, J. A.; Yudin, A. K. Cell Penetration Of Oxadiazole-Containing Macrocyles. RSC Chemical Biology 2024

Trofimova, A.; Brien, C.; Tan, J.; Trudel, V.; Yudin, A. K. An Exploration Of Regioselectivity During Formation Of Aminoboronates From Epoxides. Synlett 2024.

Appavoo, S. D.; Heller, N. W.; van Campenhout, C. T.; Saunders, G. J.; Yudin, A. K. Identification Of “Structural Pin” Interactions And Their Significance For The Conformational Control Of Macrocyclic Scaffolds. Angewandte Chemie International Edition 2024.

Diaz, D. B.; Rowshanpour, R.; Saunders, G. J.; Dudding, T.; Yudin, A. K. The Role Of Attractive Non-Covalent Interactions In Peptide Macrocylization. The Journal of Organic Chemistry 2024.

Širvinskas, M. J.; Saunders, G. J.; Yudin, A. K. Stabilization Of 3,10-Helices In Macrocycles Using Dominant Rotormethodology. Journal of the American Chemistry Society 2024.

Trofimova, A.; Dimandas, M.; Brien, C.; Khasanzoda, N.; Lough, A. J.; Yudin, A. K. Terpenoid Cyclophanes With Planar Chirality. Journal of the American Chemical Society 2024.

2023

Trofimova, A.; Brien, C.; Trinchera, P.; Tien, C. - H.; Yudin, A. K. Boryl Acrylaldehyde: An Elusive Member Of The Α-Boryl Aldehyde Class Of Reagent. Synlett 2023, 34 (18).

Dimandas, M.; Heller, N. W.; Yudin, A. K. Nitrilium Ion Trapping As A Strategy To Access Structurally Diverse Heterobiaryl-Containing Peptide Macrocycles. Chemical Science 2023, 14.

Feng, Y.; Jitkova, Y.; Keszei, A.; Sarathy, C.; Trudel, V.; J. Germain, S.; Tcheng, M.; Goncalves, M. M.; Yan, Y.; Hurren, R.; Schultz, M.; Vahidi, S.; Raught, B.; Yudin, A.; Mazhab-Jafari, M.; Schimmer, A. D. Serine Phosphorylation Marks Proteins For Degradation By The Mitochondrial Serine Protease Complex, Clpxp. Blood 2023, 142 (1).

Yang, P.; Širvinskas, M. J.; Li, B.; Heller, N. W.; Rong, H.; He, G.; Yudin, A. K.; Chen, G. Teraryl Braces In Macrocycles: Synthesis And Conformational Landscape Remodeling Of Peptides. Journal of the American Chemical Society 2023, 145 (25), 13968 - 13978.

Li, Y.; Fan, W. - X.; Luo, S.; Trofimova, A.; Liu, Y.; Xue, J. - H.; Yang, L.; Li, Q.; Wang, H.; Yudin, A. K. Β-Boron Effect Enables Regioselective And Stereospecific Electrophilic Addition To Alkenes. Journal of the American Chemical Society 2023.

2022

Tien, C. - H.; Lough, A. J.; Yudin, A. K. Iminologous Epoxide Ring-Closure. Chemical Science 2022, 13 (41), 12175 - 12179.

Diaz, D. B.; Saunders, G.; Sprang, F.; Yudin, A. K.; McTiernan, T. Navigating Complex Peptide Structures Using Macrocycle Conformational Maps. RSC Chemical Biology 2022.

Saunders, G. J.; Yudin, A. K. Property‐Driven Development Of Passively Permeable Macrocyclic Scaffolds Using Heterocycles**. Angewandte Chemie International Edition 2022.

Huh, S.; Saunders, G. J.; Yudin, A. K. Single Atom Ring Contraction Of Peptide Macrocycles Using Cornforth Rearrangement. Angewandte Chemie International Edition 2022.

Yudin, A. Synthetic Tools That Enable Synthesis And Understanding Of Bioactive Macrocycles. Synlett 2022.

Trudel, V.; Brien, C.; Tan, J.; Yudin, A. K. Towards Depeptidized Aminoboronic Acid Derivatives Through The Use Of Borylated Iminium Ions. Chemical Communications 2022.

2021

Holownia, A. E.; Apte, C. N.; Yudin, A. K. Acyl Metalloids: Conformity And Deviation From Carbonyl Reactivity. Chemical Science 2021.

Trofimova, A.; Holownia, A.; Tien, C. - H.; Širvinskas, M. J.; Yudin, A. K. Acylboronates In Polarity-Reversed Generation Of Acyl Palladium(Ii) Intermediatesacylboronates In Polarity-Reversed Generation Of Acyl Palladium(Ii) Intermediates. Organic Letters 2021, 23 (9), 3294 - 3299.

Diaz, D. B.; Appavoo, S. D.; Bogdanchikova, A. F.; Lebedev, Y.; McTiernan, T. J.; Gomes, Gdos Passos; Yudin, A. K. Illuminating The Dark Conformational Space Of Macrocycles Using Dominant Rotors. Nature Chemistry 2021.

Trudel, V.; Tien, C. - H.; Trofimova, A.; Yudin, A. K. Interrupted Reactions In Chemical Synthesis. Nature Reviews Chemistry 2021.

Kaldas, S. J.; Tien, C. - H.; Gomes, Gdos Passos; Meyer, S.; Sirvinskas, M.; Foy, H.; Dudding, T.; Yudin, A. K. Oxidative Rearrangement Of Mida ( N-Methyliminodiacetic Acid) Boronates: Mechanistic Insights And Synthetic Applications . Organic Letters 2021.

Soor, H. S.; Diaz, D. B.; Tsui, K. Yi; Calvopiña, K.; Bielinski, M.; Tantillo, D. J.; Schofield, C. J.; Yudin, A. K. Synthesis And Application Of Constrained Amidoboronic Acids Using Amphoteric Boron-Containing Building Blocks. The Journal of Organic Chemistry 2021.

Tien, C. - H.; Trofimova, A.; Shao, W.; Yudin, A. K. Synthesis Of Borylated Hydrazino Acid Derivatives.Synthesis 2021.

Soor, H. S.; Diaz, D. B.; Burton, K. I.; Yudin, A. K. Synthesis Of Fluorinated Aminoalkylboronic Acids From Amphoteric Α‐Boryl Aldehydes. Angewandte Chemie International Edition 2021, 60 (30), 16366 - 16371.DOI BibTeX RTF Tagged

Kobori, S.; Huh, S.; Appavoo, S. D.; Yudin, A. K. Two-Dimensional Barriers For Probing Conformational Shifts In Macrocycles. Journal of the American Chemical Society 2021.DOI BibTeX RTF Tagged

Ming, W.; Soor, H. S.; Liu, X.; Trofimova, A.; Yudin, A. K.; Marder, T. B. Α-Aminoboronates: Recent Advances In Their Preparation And Synthetic Applications. Chemical Society Reviews 2021, 50 (21), 12151 - 12188.DOI BibTeX RTF Tagged

2020

Huh, S.; Appavoo, S. D.; Yudin, A. K. Amidine Functionality As A Conformational Probe Of Cyclic Peptides. Organic Letters 2020.

Lebedev, Y. N.; Apte, C.; Cheng, S.; Lavigne, C.; Lough, A.; Seferos, D. S.; Aspuru-Guzik, A.; Yudin, A. K. Boramidine: A Versatile Structural Motif For The Design Of Fluorescent Heterocycles. J Am Chem Soc 2020.

Tien, C. - H.; Trofimova, A.; Holownia, A.; Kwak, B. S.; Larson, R. T.; Yudin, A. K. Carboxyboronate As A Versatile In Situ Co Surrogate In Palladium‐Catalyzed Carbonylative Transformations. Angewandte Chemie International Edition 2020.

Apte, C. Nitin; Diaz, D. B.; Adrianov, T.; Yudin, A. K. Grafting Bis(Heteroaryl) Motifs Into Ring Structures. European Journal of Organic Chemistry 2020.

Revie, N. M.; Robbins, N.; Whitesell, L.; Frost, J. R.; Appavoo, S. D.; Yudin, A. K.; Cowen, L. E. Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity Against Pathogenic Species. mSphere 2020, 5 (2).

C. Lee, F.; Tien, C. - H.; Adachi, S.; Yudin, A. K. Synthesis Of Α-Bromoacetyl Mida Boronate. Organic Syntheses 2020, 97, 157 - 171.

Yudin, A. K. Synthetic Half-Reactions. Chemical Science 2020.

2019

Holownia, A.; Tien, C. - H.; Diaz, D. B.; Larson, R. T.; Yudin, A. K. Carboxyboronate: A Versatile C1-Building Block. Angewandte Chemie International Edition 2019.

Appavoo, S. D.; Huh, S.; Diaz, D. B.; Yudin, A. K. Conformational Control Of Macrocycles By Remote Structural Modification. Chem Rev 2019.

Yamaguchi, A.; Kaldas, S. J.; Appavoo, S. D.; Diaz, D. B.; Yudin, A. K. Conformationally Stable Peptide Macrocycles Assembled Using The Petasis Borono-Mannich Reaction. Chem Commun (Camb) 2019.

Tan, J.; Grouleff, J. J.; Jitkova, Y.; Diaz, D. B.; Griffith, E. C.; Shao, W.; Bogdanchikova, A. F.; Poda, G.; Schimmer, A. D.; Lee, R. E.; Yudin, A. K. De Novo Design Of Boron-Based Peptidomimetics As Potent Inhibitors Of Human Clpp In The Presence Of Human Clpx. J Med Chem 2019, 62 (13), 6377-6390.

Smolyar, I. V.; Yudin, A. K.; Nenajdenko, V. G. Heteroaryl Rings In Peptide Macrocycles. Chem Rev 2019.

Mader, P.; Mendoza-Sanchez, R.; Iqbal, A.; Dong, A.; Dobrovetsky, E.; Corless, V. B.; Liew, S. K.; Houliston, S. R.; De Freitas, R. Ferreira; Smil, D.; Sena, C. C. Dela; Kennedy, S.; Diaz, D. B.; Wu, H.; Dombrovski, L.; Allali-Hassani, A.; Min, J.; Schapira, M.; Vedadi, M.; Brown, P. J.; Santhakumar, V.; Yudin, A. K.; Arrowsmith, C. H. Identification And Characterization Of The First Fragment Hits For Setdb1 Tudor Domain. Bioorg Med Chem 2019, 27 (17), 3866-3878.

Trudel, V.; Yudin, A. K. Nucleophilic Boron Clusters Lead To New Borylation Methods. Chem 2019.

Kaldas, S.; Kran, E.; Mück-Lichtenfeld, C.; Yudin, A.; Studer, A. Reaction Of Vinylaziridines With Arynes: Synthesis Of Benzazepines And Branched Allyl Fluorides. Chemistry – A European Journal 2019.

Soor, H. S.; Hansen, J.; Diaz, D. B.; Appavoo, S.; Yudin, A. K. Solid-Phase Synthesis Of Peptide Β-Aminoboronic Acids. Peptide Science 2019, 111 (1), e24072.

2018

Kaldas, S. J.; Yudin, A. K. Achieving Skeletal Diversity In Peptide Macrocycles Through The Use Of Heterocyclic Grafts. Chemistry - A European Journal 2018, 24 (28), 7074 - 7082.

C. Lee, F.; Diaz, D. B.; Holownia, A.; Kaldas, S. J.; Liew, S. K.; Garrett, G. E.; Dudding, T.; Yudin, A. K. Amine Hemilability Enables Boron To Mechanistically Resemble Either Hydride Or Proton. Nature Chemistry 2018, 10 (10), 1062 - 1070.

Tan, J.; Yudin, A. K. Borylated Reagents For Multicomponent Reactions. Drug Discov Today Technol 2018, 29, 51-60.

Appavoo, S. D.; Kaji, T.; Frost, J. R.; Scully, C. C. G.; Yudin, A. K. Development Of Endocyclic Control Elements For Peptide Macrocycles. Journal of the American Chemical Society 2018, 140 (28), 8763 - 8770.

Soor, H. S.; Appavoo, S. D.; Yudin, A. K. Heterocycles: Versatile Control Elements In Bioactive Macrocycles. Bioorganic & Medicinal Chemistry 2018, 26 (10), 2774 - 2779.

Kaldas, S. J.; Rogova, T.; Nenajdenko, V. G.; Yudin, A. K. Modular Synthesis Of Β-Amino Boronate Peptidomimetics. The Journal of Organic Chemistry 2018, 83 (13), 7296 - 7302.

Corless, V. B.; Holownia, A.; Foy, H.; Mendoza-Sanchez, R.; Adachi, S.; Dudding, T.; Yudin, A. K. Synthesis Of Α-Borylated Ketones By Regioselective Wacker Oxidation Of Alkenylboronates. Org Lett 2018, 20 (17), 5300-5303.

2017

Shao, W.; Kaldas, S. J.; Yudin, A. K. 3-Cyanoallyl Boronates Are Versatile Building Blocks In The Synthesis Of Polysubstituted Thiophenes. Chemical Science 2017, 8 (6), 4431 - 4436.

Denis, J. D. St.; Liew, S. K.; Scully, C. C. G.; Yudin, A. K. Activation Of Alkynylzinc Reagents By A Hemiaminal-Driven Catalytic Microenvironment. European Journal of Organic Chemistry 2017, 2017 (2), 419 - 423.

Kaldas, S. J.; O'Keefe, K. T. V.; Mendoza-Sanchez, R.; Yudin, A. K. Amphoteric Borylketenimines: Versatile Intermediates In The Synthesis Of Borylated Heterocycles. Chemistry - A European Journal 2017, 23 (41), 9711 - 9715.

Liew, S. K.; Holownia, A.; Diaz, D. B.; Cistrone, P. A.; Dawson, P. E.; Yudin, A. K. Borylated Oximes: Versatile Building Blocks For Organic Synthesis. Chem. Commun. 2017, 53 (81), 11237 - 11240.

Mendoza-Sanchez, R.; Corless, V. B.; Q. Nguyen, N. N.; Bergeron-Brlek, M.; Frost, J.; Adachi, S.; Tantillo, D. J.; Yudin, A. K. Cyclols Revisited: Facile Synthesis Of Medium-Sized Cyclic Peptides. Chemistry - A European Journal 2017, 23 (54), 13319 - 13322.

Tan, J.; III, A. B. Cognett; Diaz, D. B.; Lum, K. M.; Adachi, S.; Kundu, S.; Cravatt, B. F.; Yudin, A. K. Multicomponent Mapping Of Boron Chemotypes Furnishes Selective Enzyme Inhibitors. Nature Communications 2017, 8 (1).

C. Lee, F.; Holownia, A.; Bennett, J. M.; Elkins, J. M.; Denis, J. D. St.; Adachi, S.; Yudin, A. K. Oxalyl Boronates Enable Modular Synthesis Of Bioactive Imidazoles. Angewandte Chemie International Edition 2017, 56 (22), 6264 - 6267.

Zaretsky, S.; Yudin, A. K. Practical Medicinal Chemistry With Macrocyclescontemporary Macrocyclization Technologies; Marsault, E., Peterson, M. L., Eds.; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2017; pp 1 - 24.

Zaretsky, S.; Yudin, A. K. Recent Advances In The Synthesis Of Cyclic Pseudopeptides. Drug Discovery Today: Technologies 2017, 26, 3 - 10.

Belding, L.; Zaretsky, S.; Yudin, A. K.; Dudding, T. Retraction Of “A Mechanistic Model For The Aziridine Aldehyde-Driven Macrocyclization Of Peptides”. The Journal of Organic Chemistry 2017, 82 (8), 4512 - 4512.

Garrett, G. E.; Diaz, D. B.; Yudin, A. K.; Taylor, M. S. Reversible Covalent Interactions Of Β-Aminoboronic Acids With Carbohydrate Derivatives. Chemical Communications 2017, 53 (11), 1809 - 1812.

Chung, B. K. W.; White, C. J.; Yudin, A. K. Solid-Phase Synthesis, Cyclization, And Site-Specific Functionalization Of Aziridine-Containing Tetrapeptides. Nature Protocols 2017, 12 (6), 1277 - 1287.

Diaz, D. B.; Yudin, A. K. The Versatility Of Boron In Biological Target Engagement. Nature Chemistry 2017, 9 (8), 731 - 742.

Mazzeo, G.; Longhi, G.; Corless, V. B.; Zajdlik, A.; Yudin, A. K.; Abbate, S. Vibrational Circular Dichroism Unveils Chiroptical, Electrical, And Magnetic Properties Of Borylated Isocyanides And Aldehydes. European Journal of Organic Chemistry 2017, 2017 (35), 5262 - 5268.

2016

Scully, C. C. G.; White, C. J.; Yudin, A. K. The Effect Of Backbone Flexibility On Site-Selective Modification Of Macrocycles. Organic & Biomolecular Chemistry 2016, 14 (43), 10230 - 10237.

Liew, S. K.; Kaldas, S. J.; Yudin, A. K. A Linchpin Synthesis Of 6-Hydroxyceramides From Aziridine Aldehydes. Organic Letters 2016, 18 (24), 6268 - 6271.

Frost, J. R.; Scully, C. C. G.; Yudin, A. K. Oxadiazole Grafts In Peptide Macrocycles. Nature Chemistry 2016, 8 (12), 1105 - 1111.

Hickey, J. L.; Zaretsky, S.; Denis, M. A. St.; Chakka, S. Kumar; M. Morshed, M.; Scully, C. C. G.; Roughton, A. L.; Yudin, A. K. Passive Membrane Permeability Of Macrocycles Can Be Controlled By Exocyclic Amide Bonds. Journal of Medicinal Chemistry 2016, 59 (11), 5368 - 5376.

Low, K. E.; Ler, S.; Chen, K. J.; Campbell, R. L.; Hickey, J. L.; Tan, J.; Scully, C. C. G.; Davies, P. L.; Yudin, A. K.; Zaretsky, S. Rational Design Of Calpain Inhibitors Based On Calpastatin Peptidomimetics. Journal of Medicinal Chemistry 2016, 59 (11), 5403 - 5415.

Chung, B. K. W.; White, C. J.; Scully, C. C. G.; Yudin, A. K. The Reactivity And Conformational Control Of Cyclic Tetrapeptides Derived From Aziridine-Containing Amino Acids. Chemical Science 2016, 7 (11), 6662 - 6668.

Liew, S. K.; Holownia, A.; Tilley, A. J.; Carrera, E. I.; Seferos, D. S.; Yudin, A. K. A Study Of Boratriazaroles: An Underdeveloped Class Of Heterocycles. The Journal of Organic Chemistry 2016, 81 (21), 10444 - 10453.

Diaz, D. B.; Scully, C. C. G.; Liew, S. K.; Adachi, S.; Trinchera, P.; Denis, J. D. St.; Yudin, A. K. Synthesis Of Aminoboronic Acid Derivatives From Amines And Amphoteric Boryl Carbonyl Compounds. Angewandte Chemie International Edition 2016, 55 (41), 12659 - 12663.

Heine, N. B.; Kaldas, S. J.; Belding, L.; Shmatova, O.; Dudding, T.; Nenajdenko, V. G.; Studer, A.; Yudin, A. K. Synthesis Of Chiral Piperazinones Using Amphoteric Aziridine Aldehyde Dimers And Functionalized Isocyanides. The Journal of Organic Chemistry 2016, 81 (12), 5209 - 5216.

2015

Denis, J. D. St.; C. Lee, F.; Yudin, A. K. Access To Cyclic Amino Boronates Via Rhodium-Catalyzed Functionalization Of Alkyl Mida Boronates. Organic Letters 2015, 17 (23), 5764 - 5767.

Denis, J. D. St.; He, Z.; Yudin, A. K. Amphoteric Α-Boryl Aldehyde Linchpins In The Synthesis Of Heterocycles. ACS Catalysis 2015, 5 (9), 5373 - 5379.

Adachi, S.; Liew, S. K.; C. Lee, F.; Lough, A.; He, Z.; Denis, J. D. St.; Poda, G.; Yudin, A. K. Condensation-Driven Assembly Of Boron-Containing Bis(Heteroaryl) Motifs Using A Linchpin Approach. Organic Letters 2015, 17 (22), 5594 - 5597.

Chung, B. K. W.; Yudin, A. K. Disulfide-Bridged Peptide Macrobicycles From Nature. Organic & Biomolecular Chemistry 2015, 13 (33), 8768 - 8779.

Adachi, S.; 3rd, A. B. Cognett; Niphakis, M. J.; He, Z.; Zajdlik, A.; Denis, J. D. St.; Scully, C. C. G.; Cravatt, B. F.; Yudin, A. K. Facile Synthesis Of Borofragments And Their Evaluation In Activity-Based Protein Profiling. Chemical Communications 2015, 51 (17), 3608 - 3611.

Yudin, A. K. Macrocycles: Lessons From The Distant Past, Recent Developments, And Future Directions. Chemical Science 2015, 6 (1), 30 - 49.

Zaretsky, S.; Hickey, J. L.; Tan, J.; Pichugin, D.; Denis, M. A. St.; Ler, S.; Chung, B. K. W.; Scully, C. C. G.; Yudin, A. K. Mechanistic Investigation Of Aziridine Aldehyde-Driven Peptide Macrocyclization: The Imidoanhydride Pathway. Chemical Science 2015, 6 (10), 5446 - 5455.

Yudin, A. K. Nature’S Enzymes Tricked With Xenobiotic Oxidants. ACS Central Science 2015, 1 (2), 62 - 63.

Trinchera, P.; Corless, V. B.; Yudin, A. K. Synthesis Of Previously Inaccessible Borylated Heterocycle Motifs Using Novel Boron-Containing Amphoteric Molecules. Angewandte Chemie International Edition 2015, 54 (31), 9038 - 9041.

Zaretsky, S.; Rai, V.; Gish, G.; Forbes, M. W.; Kofler, M.; Yu, J. C. Y.; Tan, J.; Hickey, J. L.; Pawson, T.; Yudin, A. K. Twisted Amide Electrophiles Enable Cyclic Peptide Sequencing. Organic & Biomolecular Chemistry 2015, 13 (27), 7384 - 7388.

2014

He, Z.; Zajdlik, A.; Yudin, A. K. Air- And Moisture-Stable Amphoteric Molecules: Enabling Reagents In Synthesis. Accounts of Chemical Research 2014, 47 (4), 1029 - 1040.

Denis, J. D. St.; Zajdlik, A.; Tan, J.; Trinchera, P.; C. Lee, F.; He, Z.; Adachi, S.; Yudin, A. K. Boron-Containing Enamine And Enamide Linchpins In The Synthesis Of Nitrogen Heterocycles. Journal of the American Chemical Society 2014, 136 (50), 17669 - 17673.

Denis, J. D. St.; Scully, C. C. G.; C. Lee, F.; Yudin, A. K. Development Of The Direct Suzuki–Miyaura Cross-Coupling Of Primary B-Alkyl Mida-Boronates And Aryl Bromides. Organic Letters 2014, 16 (5), 1338 - 1341.

Zajdlik, A.; He, Z.; St Denis, J.; Yudin, A. Efficient Preparation Of Α-Aminoboronic Acid Derivatives Via Boroalkyl Group Migration. Synthesis 2014, 46 (04), 445 - 454.

Zaretsky, S.; Hickey, J. L.; Denis, M. A. St.; Scully, C. C. G.; Roughton, A. L.; Tantillo, D. J.; Lodewyk, M. W.; Yudin, A. K. Predicting Cyclic Peptide Chemical Shifts Using Quantum Mechanical Calculations. Tetrahedron 2014, 70 (42), 7655 - 7663.

Belding, L.; Zaretsky, S.; Rotstein, B. H.; Yudin, A. K.; Dudding, T. Shifting The Energy Landscape Of Multicomponent Reactions Using Aziridine Aldehyde Dimers: A Mechanistic Study. The Journal of Organic Chemistry 2014, 79 (20), 9465 - 9471.

White, C. J.; Hickey, J. L.; Scully, C. C. G.; Yudin, A. K. Site-Specific Integration Of Amino Acid Fragments Into Cyclic Peptides. Journal of the American Chemical Society 2014, 136 (10), 3728 - 3731.

Rotstein, B. H.; Zaretsky, S.; Rai, V.; Yudin, A. K. Small Heterocycles In Multicomponent Reactions. Chemical Reviews 2014, 114 (16), 8323 - 8359.

Treder, A. P.; Tremblay, M. - C.; Yudin, A. K.; Marsault, E. Solid-Phase Synthesis Of Piperazinones Via Disrupted Ugi Condensation. Organic Letters 2014, 16 (17), 4674 - 4677.

Zaretsky, S.; Adachi, S.; Rotstein, B. H.; Hickey, J. L.; Scully, C. C. G.; Denis, J. D. St.; Courtemanche, R.; Yu, J. C. Y.; Chung, B. K. W.; Yudin, A. K. Stereocontrolled Disruption Of The Ugi Reaction Toward The Production Of Chiral Piperazinones: Substrate Scope And Process Development. The Journal of Organic Chemistry 2014, 79 (21), 9948 - 9957.

Yudin, A. K.; Chen, G.; He, Z. Synthesis Of Functionalized 1-Azabicyclo[3.1.0]Hexanes: Studies Towards Ficellomycin And Its Analogs. HETEROCYCLES 2014, 88 (2), 1299.

He, Z.; Zajdlik, A.; Yudin, A. K. Α-Borylcarbonyl Compounds: From Transient Intermediates To Robust Building Blocks. Dalton Trans. 2014, 43 (30), 11434 - 11451.

2013

Dubovyk, I.; Watson, I. D. G.; Yudin, A. K. Achieving Control Over The Branched/linear Selectivity In Palladium-Catalyzed Allylic Amination. The Journal of Organic Chemistry 2013, 78 (4), 1559 - 1575.

Chung, B. K. W.; Hickey, J. L.; Scully, C. C. G.; Zaretsky, S.; Yudin, A. K. Bicycle Synthesis Through Peptide Macrocyclization Using Aziridine Aldehydes Followed By Late Stage Disulfide Bond Installation. MedChemComm 2013, 4 (7), 1124.

Zaretsky, S.; Scully, C. C. G.; Lough, A. J.; Yudin, A. K. Exocyclic Control Of Turn Induction In Macrocyclic Peptide Scaffolds. Chemistry - A European Journal 2013, 19 (52), 17668 - 17672.

Liew, S. K.; He, Z.; Denis, J. D. St.; Yudin, A. K. Stereocontrolled Synthesis Of 1,2- And 1,3-Diamine Building Blocks From Aziridine Aldehyde Dimers. The Journal of Organic Chemistry 2013, 78 (23), 11637 - 11645.

He, Z.; Dobrovolsky, D.; Trinchera, P.; Yudin, A. K. Synthesis Of Multisubstituted Pyridines. Organic Letters 2013, 15 (2), 334 - 337.

Zajdlik, A.; Wang, Z.; Hickey, J. L.; Aman, A.; Schimmer, A. D.; Yudin, A. K. Α-Boryl Isocyanides Enable Facile Preparation Of Bioactive Boropeptides. Angewandte Chemie 2013, 125 (32), 8569 - 8573.

2012

Rotstein, B.; Yudin, A. Aziridine-2-Carboxaldehyde Dimers Undergo Homo-Ugi 4-Component-5-Center Reactions. Synthesis 2012, 44 (18), 2851 - 2858.

Scully, C. C. G.; Rai, V.; Poda, G.; Zaretsky, S.; Burns, D. C.; R. Houliston, S.; Lou, T.; Yudin, A. K. Bending Rigid Molecular Rods: Formation Of Oligoproline Macrocycles. Chemistry - A European Journal 2012, 18 (49), 15612 - 15617.

He, Z.; Zajdlik, A.; Denis, J. D. St.; Assem, N.; Yudin, A. K. Boroalkyl Group Migration Provides A Versatile Entry Into Α-Aminoboronic Acid Derivatives. Journal of the American Chemical Society 2012, 134 (24), 9926 - 9929.

Denis, J. D. St.; He, Z.; Yudin, A. K. Chemoselective Palladium-Catalyzed Α-Allylation Of Α-Boryl Aldehydes. Organic & Biomolecular Chemistry 2012, 10 (39), 7900.

Roxin, Á.; Chen, J.; Scully, C. C. G.; Rotstein, B. H.; Yudin, A. K.; Zheng, G. Conformational Modulation Of In Vitro Activity Of Cyclic Rgd Peptides Via Aziridine Aldehyde-Driven Macrocyclization Chemistry. Bioconjugate Chemistry 2012, 23 (7), 1387 - 1395.

He, Z.; Trinchera, P.; Adachi, S.; Denis, J. D. St.; Yudin, A. K. Oxidative Geminal Functionalization Of Organoboron Compounds. Angewandte Chemie International Edition 2012, 51 (44), 11092 - 11096.

Assem, N.; Hili, R.; He, Z.; Kasahara, T.; Inman, B. L.; Decker, S.; Yudin, A. K. Role Of Reversible Dimerization In Reactions Of Amphoteric Aziridine Aldehydes. The Journal of Organic Chemistry 2012, 77 (13), 5613 - 5623.

Yudin, A. K. Synthesis Of Heterocycles Using Amphoteric Molecules. Chemistry of Heterocyclic Compounds 2012, 48 (1), 191 - 199.

Rotstein, B. H.; Winternheimer, D. J.; Yin, L. M.; Deber, C. M.; Yudin, A. K. Thioester-Isocyanides: Versatile Reagents For The Synthesis Of Cycle–Tail Peptides. Chemical Communications 2012, 48 (31), 3775.

White, C. J.; Yudin, A. K. A Versatile Scaffold For Site-Specific Modification Of Cyclic Tetrapeptides. Organic Letters 2012, 14 (11), 2898 - 2901.

2011

He, Z.; Yudin, A. K. Amphoteric Α-Boryl Aldehydes. Journal of the American Chemical Society 2011, 133 (35), 13770 - 13773.

White, C. J.; Yudin, A. K. Contemporary Strategies For Peptide Macrocyclization. Nature Chemistry 2011, 3 (7), 509 - 524.

Siebert, M. R.; Yudin, A. K.; Tantillo, D. J. The Effect Of Strain On The Rhi-Catalyzed Rearrangement Of Allylamines. European Journal of Organic Chemistry 2011, 2011 (3), 553 - 561.

Dubovyk, I.; Pichugin, D.; Yudin, A. K. Palladium-Catalyzed Ring-Contraction And Ring-Expansion Reactions Of Cyclic Allyl Amines. Angewandte Chemie International Edition 2011, 50 (26), 5924 - 5926.

Cheung, L. L. W.; He, Z.; Decker, S. M.; Yudin, A. K. Skeletal Fusion Of Small Heterocycles With Amphoteric Molecules. Angewandte Chemie International Edition 2011, 50 (49), 11798 - 11802.

Rotstein, B. H.; Mourtada, R.; Kelley, S. O.; Yudin, A. K. Solvatochromic Reagents For Multicomponent Reactions And Their Utility In The Development Of Cell-Permeable Macrocyclic Peptide Vectors. Chemistry - A European Journal 2011, 17 (44), 12257 - 12261.

2010

Assem, N.; Natarajan, A.; Yudin, A. K. Chemoselective Peptidomimetic Ligation Using Thioacid Peptides And Aziridine Templates. Journal of the American Chemical Society 2010, 132 (32), 10986 - 10987.

Afagh, N. A.; Yudin, A. K. Chemoselectivity And The Curious Reactivity Preferences Of Functional Groups. Angewandte Chemie International Edition 2010, 49 (2), 262 - 310.

Cyclohexene Imine. Organic Syntheses 2010, 87, 161.DOI BibTeX RTF Tagged

Hili, R.; Rai, V.; Yudin, A. K. Macrocyclization Of Linear Peptides Enabled By Amphoteric Molecules. Journal of the American Chemical Society 2010, 132 (9), 2889 - 2891.DOI BibTeX RTF Tagged

Jebrail, M. J.; Ng, A. H. C.; Rai, V.; Hili, R.; Yudin, A. K.; Wheeler, A. R. Synchronized Synthesis Of Peptide-Based Macrocycles By Digital Microfluidics. Angewandte Chemie International Edition 2010, 49 (46), 8625 - 8629.DOI BibTeX RTF Tagged

Cheung, L. L. W.; Yudin, A. K. Synthesis Of Highly Substituted Cyclobutane Fused-Ring Systems From N-Vinyl Β-Lactams Through A One-Pot Domino Process. Chemistry - A European Journal 2010, 16 (13), 4100 - 4109.DOI BibTeX RTF Tagged

Rotstein, B. H.; Rai, V.; Hili, R.; Yudin, A. K. Synthesis Of Peptide Macrocycles Using Unprotected Amino Aldehydes. Nature Protocols 2010, 5 (11), 1813 - 1822.DOI BibTeX RTF Tagged

2009

Vasdev, N.; van Oosten, E. M.; Stephenson, K. A.; Zadikian, N.; Yudin, A. K.; Lough, A. J.; Houle, S.; Wilson, A. A. [18F]Fluoroamines Via Ring-Opening Of N-Cbz-2-Methylaziridine With [18F]-Fluoride. Tetrahedron Letters 2009, 50 (5), 544 - 547.

Hili, R.; Yudin, A. K. Amphoteric Amino Aldehydes Reroute The Aza-Michael Reaction. Journal of the American Chemical Society 2009, 131 (45), 16404 - 16406.

De Iuliis, M. Zimmer; Watson, I. D. G.; Yudin, A. K.; Morris, R. H. A Dft Investigation Into The Origin Of Regioselectivity In Palladium-Catalyzed Allylic Amination. Canadian Journal of Chemistry 2009, 87 (1), 54 - 62.

van Oosten, E. M.; Wilson, A. A.; Stephenson, K. A.; Mamo, D. C.; Pollock, B. G.; Mulsant, B. H.; Yudin, A. K.; Houle, S.; Vasdev, N. An Improved Radiosynthesis Of The Muscarinic M2 Radiopharmaceutical, [18F]Fp-Tztp. Applied Radiation and Isotopes 2009, 67 (4), 611 - 616.

Simms, R.; Dubinsky, S.; Yudin, A.; Kumacheva, E. A Method For Fabricating Microfluidic Electrochemical Reactors. Lab on a Chip 2009, 9 (16), 2395.

Cheung, L. L. W.; Yudin, A. K. Synthesis Of Aminocyclobutanes Through Ring Expansion Of N-Vinyl-Β-Lactams. Organic Letters 2009, 11 (6), 1281 - 1284.

2008

Baktharaman, S.; Hili, R.; Yudin, A. K. Aminocarbonyl Compounds In Organic Synthesis. Aldrichim. Acta 2008, 41, 109-118.

Rasmusson, T.; L. Martyn, J. P.; Chen, G.; Lough, A.; Oh, M.; Yudin, A. K. Aromatic Fluorine As A Versatile Control Element For The Construction Of Molecules With Helical Chirality. Angewandte Chemie International Edition 2008, 47 (37), 7009 - 7012.

Siebert, M. R.; Yudin, A. K.; Tantillo, D. J. Cycloaddition/ring Opening Reaction Sequences Of N-Alkenyl Aziridines: Influence Of The Aziridine Nitrogen On Stereoselectivity. Organic Letters 2008, 10 (1), 57 - 60.

Tsang, D. S.; Yang, S.; Alphonse, F. - A.; Yudin, A. K. Stereoselective Isomerisation Of N-Allyl Aziridines Into Geometrically Stablez Enamines By Using Rhodium Hydride Catalysis. Chemistry - A European Journal 2008, 14 (3), 886 - 894.

Hili, R.; Baktharaman, S.; Yudin, A. K. Synthesis Of Chiral Amines Using Α-Amino Aldehydes. European Journal of Organic Chemistry 2008, 2008 (31), 5201 - 5213.

2007

Dubovyk, I.; Watson, I. D. G.; Yudin, A. K. Chasing The Proton Culprit From Palladium-Catalyzed Allylic Amination. Journal of the American Chemical Society 2007, 129 (46), 14172 - 14173.

Blyumin, E. V.; Gallon, H. J.; Yudin, A. K. Construction Of Three Contiguous Tertiary Stereocenters From Aziridines In One Step. Organic Letters 2007, 9 (23), 4677 - 4680.

Li, X.; Yudin, A. K. Epimerization- And Protecting-Group-Free Synthesis Of Peptidomimetic Conjugates From Amphoteric Amino Aldehydes. Journal of the American Chemical Society 2007, 129 (46), 14152 - 14153.

Yang, X.; Yudin, A. Facile Generation And Synthetic Utility Of Nitrogen-Centered Aziridinyl Radicals. Synlett 2007, 2007 (18), 2912 - 2918.

Yudin, A. K.; Hili, R. Overcoming The Demons Of Protecting Groups With Amphoteric Molecules. Chemistry - A European Journal 2007, 13 (23), 6538 - 6542.

Yekta, S.; Cheung, L.; Yudin, A. K. Polyfluorinated Phosphine Ligands In The Room Temperature Suzuki Cross-Coupling Reactions. Tetrahedron Letters 2007, 48 (45), 8048 - 8051.

Yu, L.; Kokai, A.; Yudin, A. K. Preparation And Reactivity Of Versatile Α-Amino Ketones. The Journal of Organic Chemistry 2007, 72 (5), 1737 - 1741.

2006

Watson, I. D. G.; Yu, L.; Yudin, A. K. Advances In Nitrogen Transfer Reactions Involving Aziridines. Accounts of Chemical Research 2006, 39 (3), 194 - 206.

Chen, G.; Sasaki, M.; Yudin, A. K. Facile Preparation Of Allyl Amines And Pyrazoles By Hydrazinolysis Of 2-Ketoaziridines. Tetrahedron Letters 2006, 47 (3), 255 - 259.

Krasnova, L. B.; Yudin, A. K. Highly Regioselective Transformation Of Alkenyl Bromides Into Α-Bromoaziridines And Α-Bromohydrazones. Organic Letters 2006, 8 (10), 2011 - 2014.

Hili, R.; Yudin, A. K. Making Carbon-Nitrogen Bonds In Biological And Chemical Synthesis. Nature Chemical Biology 2006, 2 (6), 284 - 287.

He, Z.; Yudin, A. K. Palladium-Catalyzed Oxidative Activation Of Arylcyclopropanes. Organic Letters 2006, 8 (25), 5829 - 5832.

Hili, R.; Yudin, A. K. Readily Available Unprotected Amino Aldehydes. Journal of the American Chemical Society 2006, 128 (46), 14772 - 14773.

Alphonse, F. - A.; Yudin, A. K. Rhodium-Catalyzed Stereoselective Formation Of Z -Enamines From Allylaziridines. Journal of the American Chemical Society 2006, 128 (36), 11754 - 11755.

Chen, G.; Sasaki, M.; Li, X.; Yudin, A. K. Strained Enamines As Versatile Intermediates For Stereocontrolled Construction Of Nitrogen Heterocycles. The Journal of Organic Chemistry 2006, 71 (16), 6067 - 6073.

2005

Siu, T.; Picard, C. J.; Yudin, A. K. Development Of Electrochemical Processes For Nitrene Generation And Transfer. The Journal of Organic Chemistry 2005, 70 (3), 932 - 937.

Watson, I. D. G.; Yudin, A. K. New Insights Into The Mechanism Of Palladium-Catalyzed Allylic Amination.Journal of the American Chemical Society 2005, 127 (49), 17516 - 17529.

Krasnova, L. B.; Yudin, A. K. Novel Nitrogen Containing Chelating Ligands From Aziridines — Preparation, Coordination Studies, And Catalytic Application In The Cyclopropanation Of Styrene. Canadian Journal of Chemistry 2005, 83 (6-7), 1025 - 1032.

Dalili, S.; Yudin, A. K. Transition Metal-Catalyzed Synthesis And Reactivity Of N -Alkenyl Aziridines. Organic Letters 2005, 7 (6), 1161 - 1164.

2004

2003

Sasaki, M.; Dalili, S.; Yudin, A. K. N -Arylation Of Aziridines. The Journal of Organic Chemistry 2003, 68 (5), 2045 - 2047.

Caiazzo, A.; Lough, A. J.; Yudin, A. K. [( R,r )-1-( N -Benzylideneamino)-2-(Diphenylphosphino)Cyclohexane-Κ 2 N,p ]Dichloro(Triphenylphosphine-Κ P )Ruthenium(Ii). Acta Crystallographica Section E Structure Reports Online 2003, 59 (7), m399 - m401.

Caiazzo, A.; Dalili, S.; Yudin, A. K. Lewis Acid-Catalyzed Dimerization Of N-Unprotected Aziridines. Synlett 2003, No. 14, 2198 - 2202.

Chen, Y.; Yekta, S.; Yudin, A. K. Modified Binol Ligands In Asymmetric Catalysis. Chemical Reviews 2003, 103 (8), 3155 - 3212.

Sasaki, M.; Yudin, A. K. Oxidative Cycloamination Of Olefins With Aziridines As A Versatile Route To Saturated Nitrogen-Containing Heterocycles. Journal of the American Chemical Society 2003, 125 (47), 14242 - 14243.

Watson, I. D. G.; Yudin, A. K. Ring-Opening Reactions Of Nonactivated Aziridines Catalyzed By Tris(Pentafluorophenyl)Borane. The Journal of Organic Chemistry 2003, 68 (13), 5160 - 5167.

Chen, Y.; Yudin, A. K. Synthesis Of 3-Aminoaspartic Acid Derivatives From Glycine Precursors. Tetrahedron Letters 2003, 44 (26), 4865 - 4868.

2002

Caiazzo, A.; Dalili, S.; Yudin, A. K. Design And Development Of Cyclohexane-Based P,n-Ligands For Transition Metal Catalysis. Organic Letters 2002, 4 (15), 2597 - 2600.

Siu, T.; Yudin, A. K. Electrochemical Imination Of Sulfoxides Using N -Aminophthalimide. Organic Letters 2002, 4 (11), 1839 - 1842.

Siu, T.; Yudin, A. K. Practical Olefin Aziridination With A Broad Substrate Scope. Journal of the American Chemical Society 2002, 124 (4), 530 - 531.

Watson, I. D. G.; Yudin, A. K. Selective Functionalization Of Small Organic Molecules Using Electrophilic Nitrogen Sources. Curr Opin Drug Discov Devel 2002, 5 (6), 906-17.

2001

Yudin, A. K.; Siu, T. Combinatorial Electrochemistry. Current Opinion in Chemical Biology 2001, 5 (3), 269 - 272.

Pandiaraju, S.; Chen, G.; Lough, A.; Yudin, A. K. Generation Of Highly Enantioselective Catalysts From The Pseudoenatiomeric Assembly Of Binol, F 8 Binol, And Ti(O I Pr) 4. Journal of the American Chemical Society 2001, 123 (16), 3850 - 3851.

Yudin, A. K.; Chiang, J. P.; Adolfsson, H.; Copéret, C. Olefin Epoxidation With Bis(Trimethylsilyl) Peroxide Catalyzed By Inorganic Oxorhenium Derivatives. Controlled Release Of Hydrogen Peroxide. The Journal of Organic Chemistry 2001, 66 (13), 4713 - 4718.

Siu, T.; Li, W.; Yudin, A. K. Parallel Electrosynthesis Of 1,2-Diamines. Journal of Combinatorial Chemistry 2001, 3 (6), 554 - 558.

Pandiaraju, S.; Lough, A.; Yudin, A. K. Toward New Coordination Environments And Molecular Architectures Using F 8 Binol, An Electron-Poor Isostere Of Binol. Israel Journal of Chemistry 2001, 41 (4), 309 - 312.

2000

Martyn, L. J. P.; Pandiaraju, S.; Yudin, A. K. Catalytic Applications Of F8Binol: Asymmetric Oxidation Of Sulfides To Sulfoxides. Journal of Organometallic Chemistry 2000, 603 (1), 98 - 104.

Adolfsson, H.; Copéret, C.; Chiang, J. P.; Yudin, A. K. Efficient Epoxidation Of Alkenes With Aqueous Hydrogen Peroxide Catalyzed By Methyltrioxorhenium And 3-Cyanopyridine. The Journal of Organic Chemistry 2000, 65 (25), 8651 - 8658.

Yudin, A. K.; L. Martyn, J. P.; Pandiaraju, S.; Zheng, J.; Lough, A. F 8 Binol, An Electronically Perturbed Version Of Binol With Remarkable Configurational Stability. Organic Letters 2000, 2 (1), 41 - 44.

Siu, T.; Yekta, S.; Yudin, A. K. New Approach To Rapid Generation And Screening Of Diverse Catalytic Materials On Electrode Surfaces. Journal of the American Chemical Society 2000, 122 (48), 11787 - 11790.

Siu, T.; Li, W.; Yudin, A. K. Parallel Electrosynthesis Of Α-Alkoxycarbamates, Α-Alkoxyamides, And Α-Alkoxysulfonamides Using The Spatially Addressable Electrolysis Platform (Saep). Journal of Combinatorial Chemistry 2000, 2 (5), 545 - 549.

Chen, Y.; Yekta, S.; L. Martyn, J. P.; Zheng, J.; Yudin, A. K. Regioselective Substitution Of Fluorine In F 8 Binol As A Versatile Route To New Ligands With Axial Chirality. Organic Letters 2000, 2 (22), 3433 - 3436.